JAK2V617F mutation and myeloproliferative disorders in splanchnic vein thrombosis
نویسندگان
چکیده
منابع مشابه
Role of the JAK2 mutation in the diagnosis of chronic myeloproliferative disorders in splanchnic vein thrombosis.
The diagnosis of an underlying chronic myeloproliferative disorder (CMPD) is often problematic in patients with primary extrahepatic portal vein obstruction (EHPVO) or Budd-Chiari syndrome (BCS); indeed, conventional clinical and hematological parameters usually yield insufficient information. To assess the diagnostic contribution of the gain-of-function mutation V617F of the JAK2 gene, 93 pati...
متن کاملSplanchnic vein thrombosis, the onset manifestation in JAK positive Chronic Myeloproliferative Disorders Neoplasms
BACKGROUND Patients with Myeloproliferative Neoplasms-(MPN) have a high risk of thrombotic complications. Portal vein thrombosis is a severe complication, which in many cases, appears at the onset of the disease; the risk factors are related to the presence of qualitatively altered thrombocytes and leucocytes, leading to their activation and appearance of leukocytes-platelet-aggregates; anomali...
متن کاملLatent Myeloproliferative Neoplasm as a Cause of Idiopathic Splanchnic Vein Thrombosis: The Role of JAK2V617F Mutation and Bone Marrow Biopsy Evaluation
Abbreviations: MPN: Myeloproliferative Neoplasms; PV: Polycythemia Vera; ET: Essential Thrombocythemia; PMF: Primary Myelofibrosis; CBC: Complete Blood Count; SVT: Splanchnic Veins Thrombosis; PVT: Portal Vein Thrombosis; BCS: Budd Chiari Syndrome; AST: Aspartate Amino Transferase; ALT: Alanine Aminotransferase; WBC: White Blood Cell count; CT: Computed Tomography; Ig: Immunoglobulin; ADP: Aden...
متن کاملSplanchnic vein thrombosis
Splanchnic vein thrombosis (SVT) – including mesenteric, portal, splenic and supra-hepatic veins thrombosis – is an underdiagnosed disease, with heterogeneous clinical presentations and a non-negligible rate of incidental findings. The main risk factors include abdominal diseases or interventions (e.g. infections, cirrhosis, abdominal cancer or surgical procedures), haematological disorders (ma...
متن کاملThe JAK2V617F mutation in polycythemia vera and other myeloproliferative disorders: one mutation for three diseases?
The discovery of the JAK2V617F mutation has made the diagnosis of polycythemia vera (PV) much easier, but the pathogenesis of PV is still incompletely understood. In particular, it is not yet elucidated how a single mutation can be found in multiple myeloproliferative disorders (MPD) and myelodysplastic syndromes with ring sideroblasts and whether the sole JAK2V617F is sufficient to induce a MP...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2011
ISSN: 0269-2813
DOI: 10.1111/j.1365-2036.2010.04533.x